THE PURIFICATION OF PROTHROMBIN
نویسندگان
چکیده
منابع مشابه
Partial Purification of Human Prothrombin
Independently and almost simultaneously a number of investigators recognized the fact that at least two plasma factors are important in the conversion of prothrombin to thrombin in the presence of tissue thromboplastin and calcium. Various names have been applied to these factors and, at a recent Macy Conference on blood clotting (1), most of the investigators agreed that they could be grouped ...
متن کاملPurification and characterization of a variant of human prothrombin: prothrombin Segovia.
A dysprothrombin designated prothrombin Segovia was isolated from the plasma of an individual with normal prothrombin antigen and prothrombin activity lesser than 25% of the control prothrombin activity. Activation by prothrombinase complex showed a lower amidolytic than clotting activity, which suggests a lesser generation of active intermediates than normal prothrombin. When prothrombin Segov...
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We wish to describe certain simplifications in the technique previously described (13, 14) for the purification of prothrombin and thrombin. With new adaptations it is possible to process large quantities of plasma and at the same time to obtain products 2 to 5 times as potent as those previously reported from this laboratory. A brief survey of the chemical properties of these newly obtained pr...
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Blood Coagulation Induced by Iranian Saw-Scaled Viper (Echis Carinatus) Venom: Identification, Purification and Characterization of a Prothrombin Activator
Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity. Materials and Methods: In order to study the mechanism ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1941
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51361-2